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Stachulski AV, Knausenberger TB, Shah SN, Hoyles L, McArthur S (2023) A hostgut microbial amino acid co-metabolite, p-cresol glucuronide, promotes bloodbrain barrier integrity in vivo
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This insight, which implied that a substance could be harmful at a high dose but beneficial or benign at a low one, directly prefigured the biphasic dose-responses central to hormesis and laid the groundwork for modern toxicology
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