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Additionally, based on density functional theory, we developed a computational model to predict the K d values and the trend of reaction kinetics of Michael addition reactions 30

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ROS metabolism and H 2 O 2 -mediated redox signaling regulation ROS primarily arise from the metabolic activities of mitochondria and peroxisomes

2.1.4 Impact on cell signaling Emerging studies indicate molecular hydrogen may also alter miRNAs, MAP kinases like p38, PPAR, and other cell signaling molecules to elicit cytoprotection [27]