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Many studies have revealed numerous additional functions of glucagon in the brain, liver, heart, and adipose tissue in addition to its well-known function in regulating blood sugar levels [30,31,32]
Now is the time to move forward with an enrollment plan
Figure 1 from Colhoun , et al, Nat Med 2024 Even if semaglutide saves lives, hearts, and kidneys, and FLOW is a global trial, implementation of the so-called fourth pillar remains a local challenge
Notably, four of the seven core targets were linked to the regulation of ECM deposition and remodeling, processes relevant to atherosclerotic plaque formation
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