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We acknowledge support the Abdul Latif Jameel Clinic from the Machine Learning for Pharmaceutical Discovery and Synthesis (MLPDS) consortium, the MATCHMAKERS project supported by the Cancer Grand Challenges partnership (funded by Cancer Research UK (CGCATF2023/100001), the National Cancer Institute (OT2CA297463) and The Mark Foundation for Cancer Research), the DTRA Discovery of Medical Countermeasures Against New and Emerging (DOMANE) threats program, the NSF Expeditions grant (award 1918839) Understanding the World Through Code, and the DSO Singapore grant on next generation techniques for protein ligand binding

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It refers to identifying the most appropriate pathway based on individual factors including: Medical eligibility: Determined by a licensed clinician based on health history and contraindications Regulatory framework: FDA-approved finished products versus compounded formulations Access method: In-person prescription, telehealth evaluation, or insurance-covered treatment Cost structure: Retail pricing, insurance coverage, or cash-pay telehealth programs Monitoring requirements: Level of medical supervision appropriate for individual circumstances No single pathway is universally "best." The appropriate choice depends on individual medical circumstances, financial capacity, and regulatory comfort levelfactors that only the individual and their healthcare provider can properly evaluate

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