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doi: 10.1016/j.plaphy.2023.108259 122 HeCWangJZhangZYangMLiYTianXet al
Vitamin B12 is essential in body functions like the formation of red blood cells, DNA synthesis, and the proper function of the nervous system
00:10:27 Vickie Danaher But studies suggest that there may be a somewhat higher discontinuation rate with orforglipron compared with oral semaglutide, potentially due to these GI side effects
Cost remains a barrier with a persons income being a major factor in determining compliance with GLP1-RAs (Rodriguez et al., 2025)
Theoretical and mechanistically predicted concerns for example, the consequences of chronically stimulating the GH/IGF-1 axis, or the metabolic implications of ghrelin-pathway activation and appetite stimulation have not been resolved by long-term human trials
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