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TLDR summary of PIONEER 4 & 6 trials: The oral semaglutide 14mg group achieved a 1.2% reduction in HbA1c and 4.3kg of weight loss, outperforming the liraglutide group

If youre experiencing any symptoms that could be side effects of GLP-1s, contact your healthcare provider

Decision framework: Start existing treatments (semaglutide or tirzepatide) if: Your health risks from obesity are significant and immediate (uncontrolled diabetes, severe sleep apnea, cardiovascular disease) You have access to approved therapies through insurance or can afford them You need proven, FDA-approved medications with established safety profiles Waiting 1-2+ years for retatrutide approval doesnt align with your health timeline Consider waiting if: Youre currently at a stable weight with controlled health conditions Youve tried semaglutide or tirzepatide and hit a plateau but tolerated them well Youre in a position to potentially enroll in a retatrutide clinical trial You understand waiting means continued health risks from obesity Dont wait if: You think retatrutide will be a magic bullet with no downsides Your doctor is recommending treatment now for medical reasons Youre using waiting for the next best thing as an excuse to avoid addressing the problem The lifestyle component is non-negotiable regardless of which medication you use: High protein intake (0.7-1g per pound of body weight daily) to preserve muscle during weight loss

I am a Medical D Im going to do a check in everyday to monitor my progress.Ill be telling my story to let everyone know why Im taking it but Im excited

Salehi M, Gastaldelli A, DAlessio DA