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3.1.2 The gut microbiota modulates gastrointestinal motility by influencing the intestinal barrier Impaired intestinal barrier function represents a critical pathological basis for motility disorders ( Lacticaseibacillus paracasei (basonym Lactobacillus paracasei ), enhance the mechanical integrity of the intestinal mucosa by upregulating the expression of tight junction proteins (claudin-1, ZO-1, Occludin), thereby reducing LPS translocation across the epithelium (Su et al., 2024)