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Copper in its metallic state has no effect on the skin and it becomes a potential irritant or allergen when it is corroded to become soluble through the action of exudates encountered on the skin surface, or in a relatively corrosive physiological environment such as the oral cavity or the uterus 3

These findings suggest that the risk score may inform the selection of therapeutic agents, with certain drugs being potentially more effective in high-risk patients

Further experiments to clarify this point gave surprising results

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Transdermal delivery systems in cosmetics