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Early-life stress and cannabinoid exposure each induce structural and molecular alterations within these circuits, including reduced cortical thickness, synaptic loss, and dendritic atrophy in the PFC, and diminished dopamine receptor expression and sensitivity in the NAc [13,14,15,16]

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Poor diet: Inadequate consumption of fruits, vegetables, and sulfur-rich foods leads to the reduction of glutathione

The level of NAD + decreases with aging and the cumulative effects of oxidative stress ratios of NADP + and NADPH gradually shifts to higher NADP + relative to NADPH

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