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Estrogen levels fluctuate erratically before declining, progesterone drops more steeply and earlier, and the parallel age-related decline in growth hormone pulse amplitude accelerates, compounding symptoms like poor sleep, abdominal fat accumulation, and reduced lean mass
Acta 329 (1-2), 2338
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Studies have shown that in IRI models, HO levels are elevated by tens of times compared to normal conditions, and ROS such as O, HO, andOH accumulate exponentially, far exceeding the scavenging capacity of endogenous antioxidant systems such as SOD and glutathione peroxidase (GSH-Px), leading to severe oxidative stress [22]
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