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For that reason, it is more accurate to call copper a theoretical concern with prolonged exposure than to say that longer KLOW cycles are proven to cause copper buildup
However, this phosphorylation was blocked by the GLP-1-R-Antagonist Exendin(9-36), emphasizing the role of GLP-1-mediated signaling [16]
If that holds up in prospective studies, it changes how we think about this disease entirely, and this finding provides a strong rationale for further mechanistic and clinical studies focused on endometrial cancer prevention and treatment. The most dramatic drops in risk, where this reduction was by 50% or more, also occurred in multiple myeloma, pancreatic cancer, and colorectal cancer, in addition to endometrial cancer
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