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In published in-vitro pharmacology, the molecule shows full agonist activity at GLP-1R and GIPR with somewhat attenuated potency at GCGR, a profile designed to bias signaling toward energy expenditure while limiting hyperglycemic risk in preclinical assays (Coskun et al., 2022)
doi:10.3748/wjg.v23.i29.5304 39
The scientists looked at the health records of more than 95,000 patients, including 22,480 people who used GLP-1s
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