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We hypothesize that adding a long-acting GLP-1-RA can increase basal GLP-1 levels and, in combination with native post-prandial GLP-1 bolus restored after MBS, may be considered as a basal-bolus treatment for individuals with MBS failure (Fig
Moreover, branched-chain amino acids (BCAAs) and their catabolic products, which are associated with the risk of obesity, insulin resistance, and T2DM, are significantly reduced by tirzepatide (37)
10.1007/s00125-023-06060-w 43 GaoY.YangG.ZhouY
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