If something is interfering with absorption, or your levels are low and need correcting, an injection is usually the more reliable route
L-arginine provides an immediate boost to nitric oxide production, while L-citrulline creates a sustained release that extends the benefits over a longer period
Nutrients 12 , 3665 (2020)
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cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients