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Whilst GIP receptors are also present on pancreatic beta cells and adipocytes, their role in glucose homeostasis has been debated

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For patients with a history of treated and stable malignancies, tesamorelin therapy should be initiated only after careful evaluation of the potential benefit of treatment relative to the risk of re-activation of the underlying malignancy

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This approach not only enhances the bioavailability of drugs but also provides flexibility in administration routes, from oral and transdermal to pulmonary and ocular delivery