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Amylin, a neuroendocrine hormone co-released with insulin, controls hunger, gastric motility, glucagon secretion, and energy metabolism via divergent amylin receptor (AMYR) subtypes (1-3), namely the calcitonin receptor (CTR) and the receptor activity-modifying proteins (RAMPs)
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not only is it an essential mechanical structure for cells to maintain normal organ function and transducing extracellular mechanical signals to stimulate cellular responses, but it also forms the microenvironment that enables stromal and parenchymal interactions
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