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Fistulas are a major Crohns disease complication, and this is one of the more clinically relevant preclinical findings
Drugs such as metformin activate the energy sensor AMPK, thereby promoting mitochondrial biogenesis and functiona metabolic cornerstone for memory T-cell development that supports the transition from exhaustion to a memory-precursor state [374]
In healthy, resting cells, the ratio of reduced glutathione to oxidized glutathione is typically greater than 100:1
J Biol Chem 259:90829089 Nagy-Szakal D, Barupal DK, Lee B, Che X, Williams BL, Kahn EJR, Ukaigwe JE, Bateman L, Klimas NG, Komaroff AL, Levine S, Montoya JG, Peterson DL, Levin B, Hornig M, Fiehn O, Lipkin WI (2018) Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics
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