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Combining these inhibitors with traditional immunosuppressants like corticosteroids or hydroxychloroquine may improve treatment efficacy and patient outcomes by addressing both immune dysregulation and oxidative damage in SLE (120)

Study Design Details Participants in STEP-1 also received counseling on diet and exercise, with recommendations to reduce daily caloric intake by 500 calories and increase physical activity to 150 minutes per week

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Patients who experience rapid weight loss should undergo gallbladder ultrasonography to screen for imminent biliary pathology