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Extended 15-year follow-up studies showed that treatment prevented age-related impairment of physical endurance, normalized circadian rhythm of melatonin production, and improved carbohydrate and lipid metabolism markers

doi: 10.1016/j.redox.2022.102541 67 WuXLiYZhangSZhouX

Research on contestants from The Biggest Loser showed metabolic suppression lasting at least six years after their weight loss

It is a completely separate signaling cascade from the one GHRH uses, which is precisely why combining the two produces synergistic rather than additive effects on growth hormone output

This selectivity makes it a preferred tool in GH research where hormonal specificity matters