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The most common risks of oral GLP-1s like Rybelsus, Wegovy pill, and Foundayo include : Acute pancreatitis Diabetic retinopathy complications (diabetes-related vision changes) Hypoglycemia (low blood sugar), especially when used with insulin Kidney or gallbladder issues Severe gastrointestinal reactions Allergic reactions Pulmonary aspiration during general anesthesia or deep sedation All three GLP-1s also carry a black box warning for thyroid tumors based on animal studies