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The construct incorporates an N-terminal nona-D-arginine (D-Arg)9 cell-penetrating tag fused to a segment derived from the FOXO4-p53 interaction domain, giving the peptide a strongly cationic overall character driven by its multiple arginine and lysine residues, along with a single tryptophan that supports UV monitoring at 280 nm during analytical workflows

New England Journal of Medicine, Aug 14, 2025

The batch-specific COA is included with every order

Its amino acid sequence and structural characteristics provide some resistance to degradation

Oral supplements present a more convenient option, albeit with slower and subtler results