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Quick Reference: Injection site reactions: 15-25% (mild, resolve in 2-24 hours) Nausea: 5-10% (transient, first week) Dizziness: 3-7% (occasional, brief) Serious events: Zero documented in 100+ animal studies Typical dose: 250-500 mcg/day SubQ
Vitamin C also inhibits the enzyme tyrosinase and thus contributes to the decrease in melanin production
The FDA did not raise any concerns regarding OLCs preclinical, clinical, or safety data included in the original NDA submission
Nat Med (2002) 8(7):6434.10.1038/nm0702-643 80 TschopMSmileyDLHeimanML
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