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Weeks 9+ (semaglutide 1.0mg+): Increase creatine to 5 grams daily if tolerated

Peripheral Neuropathy Diabetic Neuropathy Guidelines from the American Society of Pain and Neuroscience (ASPN) state that, although dietary supplements including acetyl-L-carnitine may have a role in managing painful diabetic neuropathy, there is insufficient high-quality evidence comparing ALCAR to typical pharmacologic drugs, and there is not enough information about safe dosing, to recommend for or against its use [7][24]

Cornea 31 (1), 7480

Up to 92% of participants on tirzepatide achieved an A1C of less than 7%the ADAs recommended target for most people with diabetes

Keep a symptom diary noting pain location, severity (on a 0-10 scale), timing relative to meals and medication doses, and associated symptoms