This is consistent across the GLP-1 class, as the STEP UP trial showed dramatically higher dysesthesia rates at higher semaglutide doses
We hypothesise that the absence of glucagon leads to improved oral glucose tolerance similar to that seen in glucagon receptor knockout mice, which also have minimal glucose excursions after an oral glucose load
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Discussion Our findings demonstrate that GLP-1 receptor agonist-based therapeutics significantly disrupt the interoceptive stimulus effects of alcohol, highlighting a potential therapeutic mechanism through which these medications may reduce alcohol consumption and motivation