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In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Cadenas and Davies, 2000)

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People with methionine deficiency may have poor detoxification of xenobiotics and sulfhydryl reactive metals (mercury, lead, arsenic, and cadmium), or present with fatty liver or biliary insufficiency occlusive arterial disease

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