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In hospital settings, it is also used as an antidote for paracetamol overdose (IV formulation at doses of up to 150mg/kg) and in nebulized format in patients with acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis)

Together, this evidence suggests that stress-induced BBB dysfunction associated with combat may have allowed pyridostigmine to penetrate the brain and exert central neurotoxic effects that are characteristic of Gulf War Syndrome

However, many doctors are unaware of the significance of these mutation