According to FDA communications: "The FDA does not verify the safety, effectiveness, or quality of compounded drugs before they are marketed." Compounded semaglutide formulations have not undergone independent clinical trials as finished products
Hansen M, Scheltema MJ, Sonne DP, Hansen JS, Sperling M, Rehfeld JF, et al
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The reasoning mirrors how tissue remodeling is thought to work
Their results also showed that glucagon was higher in kidney disease patients despite their insulin levels being the same