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Furthermore, recent evidence has revealed that TLR7 augments the adenosine (cAMP)-protein kinase A (PKA) pathway, ultimately leading to increased expression of sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase (SERCA) and ryanodine receptor 2 (RYR2) in the sarcoplasmic reticulum, thereby disrupting Ca 2+ signaling within cardiomyocytes

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