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In large-scale longer-term cardiovascular outcomes trials [47, 48, 84], long-term DPP-4 inhibition was associated with no change or a small decline in glomerular function that persisted during the entire duration of follow-up (up to 4 years)

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The first dose is the most likely to produce mild nausea, fatigue, and changes in bowel patterns

The scientists found that between 2017 and 2022: Average total payments per patient increased 157% among adults without diabetes and 36% among those with diabetes Despite rising total payments, average out-of-pocket payments per patient declined 26% among adults without diabetes and 39% among those with diabetes GLP-1 use increased 643% among adults without diabetes and 230% among adults with diabetes Semaglutide became the dominant GLP-1 drug by 2022, accounting for 54% of usage among adults with diabetes and 65% among adults without diabetes The authors note that while this study only used data through 2022, Medicare and Medicaid spending on GLP-1s has continued to surge in recent years

Reviewing your specific BCBS plan documents or calling your insurer directly remains the only reliable way to determine your individual coverage status, as blanket statements about BCBS coverage cannot apply across all plans