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While these results come primarily from the Khavinson research group in Russia and have not been independently replicated, they represent the most extensive human data available on pineal peptide supplementation
Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results
It does not act like a traditional sedative but may promote sleep by influencing delta wave activity in the brain
Researchers concerned about rebound effects after stopping GLP-1 therapies may find this mechanism particularly appealing
