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It is generally well-absorbed and may be less likely to cause diarrhea compared to magnesium citrate or oxide
However, there are exceptions involving use of the medication for weight loss in conjunction with treatment for certain medical conditions, such as cardiovascular disease
Insilicos "Mission Impossible": Designing the Ideal GLP-1 with AI For Once-a-Week Dosing The ideal GLP-1 drug must achieve a delicate balance: an oral small molecule that is highly efficacious, possesses a superior safety and tolerability profile, and offers maximum convenience
Kidney function actually often improves with GLP-1 therapy due to weight loss and anti-inflammatory effects
Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1
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