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Key SURMOUNT-5 findings UK patients should know Mounjaro produced 20.2% average weight loss vs Wegovys 13.7% in the same trial, at the same time, with the same population Nearly twice as many Mounjaro patients achieved 20%+ weight loss (31.6% vs 16.1%) Three times as many Mounjaro patients achieved 25%+ weight loss (15.4% vs 5.0%) indicating Mounjaros advantage is more pronounced at higher levels of weight loss Tolerability was comparable discontinuation rates due to adverse events were similar between the two medications The practical implication is clear: for patients where maximum weight loss is the primary goal and cost is not a barrier, SURMOUNT-5 provides strong evidence for choosing Mounjaro
Modifications are also being designed to create biased agonists
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