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Given the relatively limited endogenous antioxidant capacity of the brain, elevated ROS levels are more likely to elicit neurotoxic effects
Importantly, the enteric nervous system (ENS) operates in conjunction with extrinsic innervation from sympathetic and parasympathetic branches of the autonomic nervous system 16,17 , which provide top-down modulation of gut physiology, including the regulation of intestinal motility 18 , epithelial secretion 19 , and visceral sensation 20
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For companies looking to manage the costs, the solution to the problem is just making it more difficult to get the drugs, Ameet Sarpatwari, a drug-pricing expert at Harvard, told me
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