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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo

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The rotarod test assessed motor stability, coordination, and pain using a Rotarod apparatus (Jinan Yiyan Scientific Instruments Co., Ltd., China)

12 have proposed the synthesis and evaluation of ebselen derivatives 7a-c , Figure 2