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However, melatonin is not exclusively produced in the pineal gland, but it is also locally synthesized in several cells and tissues, such as the retina, the gastrointestinal tract, and the innate immune system 10

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Expressions of TNF-, IL-6, NFB's p65, and p38 are frequently upregulated in cancer and have been associated with tumor progression

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Stoffel, Ulrike Hoerler Koerner, et al

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