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Abbreviations sPTB: Spontaneous preterm birth PTB: Preterm birth PPROM: Preterm premature rupture of membranes GA: Gestational age BMI: Body mass index LMP: Last menstrual period IVF: In vitro fertilization LCMS/MS: Liquid chromatographytandem mass spectrometry ELISA: Enzyme-linked immunosorbent assay AUC: Area under the receiver operating characteristic curve ROC: Receiver operating characteristic CI: Confidence interval OR: Odds ratio SD: Standard deviation IQR: Interquartile range FDR: False discovery rate DEG: Differentially expressed gene GPX3: Glutathione peroxidase 3 NID1: Nidogen 1 PAPPA2: Pregnancy-associated plasma protein A2 IBP4: Insulin-like growth factor-binding protein 4 SHBG: Sex hormone-binding globulin IRB: Institutional Review Board References American College of O, Gynecologists: Prediction and prevention of spontaneous preterm birth: ACOG Practice Bulletin, Number 234

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It upregulates genes that code for collagen I, III, and IV while simultaneously suppressing genes associated with collagen degradation

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