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The most common side effects are usually gastrointestinal (GI) related, namely nausea and vomiting
Scientific Reports DOI:10.1038/s41598-026-60835-w Abstract Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ) generation during aging
The study was designed to have 80% power to detect a treatment effect between the clusters, assuming that the true difference in treatment effect between clusters was 3 mmol mol 1 (which would be clinically relevant given previous reports on the association between HbA1c and vascular complications 31 )
So bile acids trigger the release of GLP-1 as well
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