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Which patients does the article describe as possible candidates for adding bupropion

Increased expression of the FMO3 gene could be a culprit in atherosclerosis and CVD.8 FMO3 may have adverse effects on blood lipids and glucose independently of TMAO formation, although more research is needed.15 Also, in the liver, trimethyllysine (TML), a modified amino acid, can be converted to GBB and then to carnitine and potentially to TMA and TMAO

Nausea and most gastrointestinal side effects typically resolve within 1-2 weeks as medication concentration drops, though some patients report mild digestive changes into week 3-4

Constipationdefined as having fewer than three bowel movements per week, hard or dry stools, or difficulty or pain with passage of stoolis a recognized adverse effect of GLP-1 receptor agonists, though it occurs less frequently than nausea or diarrhea

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