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Most researchers switch from one to the other rather than running both

B12 plays a crucial role in several vital functions: Red blood cell formation B12 is essential for producing healthy red blood cells that carry oxygen throughout your body DNA synthesis Required for cell division and replication, including the rapidly dividing cells in hair follicles Nervous system function Maintains the protective myelin sheath around nerves Energy metabolism Helps convert food into usable energy Protein synthesis Supports the production of keratin, the protein that makes up your hair Because B12 is involved in so many fundamental processes, a deficiency can affect multiple body systems including your hair

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"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

Durcik M, Gramec SD, Tomasic T, Trontelj J, Peterlin ML