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For decades, the mechanistic explanation for this protection has been anchored in two canonical pathways: the activation of the Nrf2-mediated antioxidant response and the inhibition of histone deacetylases (HDACs) (5, 6)
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Early phase 2 data showed average weight loss of approximately 24 percent at 48 weeks, with the STEP UP trial demonstrating 20.7 percent average weight reduction with the higher dose formulation at 72 weeks
Am J Dermatopathol 2015
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