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Among these alleles, 4 were obtained from lines collected before the use of DDT and so it is unlikely that the G171K change occurred in response to DDT selection

Consistent with this, the depletion of butyrate-producing bacteria and the concomitant reduction in intestinal butyrate levels reported in IBD patients compared with healthy individuals have highlighted the immunomodulatory role of this microbial metabolite (91, 100102)

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It works with the body's systems, not against them

The role of the enzyme is to produce NADPH, a factor that helps glutathione to fight against free radicals and thereby protect the cells from oxidative stress and damage