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Description

Regarding immunomodulatory strategies, emerging approaches such as multi-target cytokine inhibitors (e.g., simultaneously targeting IL-1 and TNF-), immune cell-targeted therapies (e.g., promoting M2 macrophage polarization or Treg cell expansion), and metabolic reprogramming(Such as neutralizing mitochondrial ROS, protecting chondrocytes from oxidative stress damage) show great potential

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Only about 10% of the secreted GLP-1 is delivered to the pancreas in its active form, while the rest is rapidly converted to inactive metabolites

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