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For weekly semaglutide injections, minor changes in injection time are acceptable
Its value therefore lies in providing a well-characterised single-pathway GLP-1 model , making it the logical comparator for newer incretin compounds
Hu H, Ding J, Zhang S, Li Y, Bai L, Yuan N
1 Thus, numerous studies have used biotechnology to extend the half-life of GLP-1 RAs, with strategies including amino acid sequence substitution, fatty acid conjugation with a linker, fusion of albumin or the IgG fragment crystallizable (Fc) region (Figure 1)
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