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The extracellular subunit (130 KDa) is sialylated via 2, 6-linkages and binds the IGF-1R ligands (IGF-1, IGF-2), while the intracellular subunit (97 kDa) transmits a downstream signal by autophosphorylating tyrosine residues
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In addition to analysis in blood and urine, acylcarnitine profiling can also be done in cultured fibroblasts after a fatty acid loading test [41]
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