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This modification stabilizes YAP by preventing its ubiquitylation and degradation allowing it to accumulate and promote gene transcription that supports tumorigenesis and chemoresistance

All providers exercise independent medical judgment and may prescribe, adjust, pause, or decline treatment, including GLP-1 therapies such as semaglutide and tirzepatide, based on clinical appropriateness, patient history, contraindications, and applicable state laws

Some research suggests human C-cells may not respond to GLP-1 activation same way at all

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