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(2021) provides a concise description and outlines the advantages of various VCO extraction methods

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In the ischemic environment, microglia tend to polarize toward the M1 phenotype, releasing pro-inflammatory factors such as IL-1 and TNF-, while also activating oxidative stress and matrix metalloproteinases, leading to degradation of tight junction proteins and endothelial dysfunction (138)

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Plus, this shows that these drugs could be beneficial for other conditions made worse by chronic inflammation