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202 Under normal conditions, acetylcholine and cholecystokinin within physiological ranges induce Ca exocytosis in the granular area at the acinar tip and extracellular trypsinogen secretion via IP 3 R or nicotinic acid adenine dinucleotide phosphate without activating trypsinogen stored in granules
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Additionally, GLP-1 promotes the growth and proliferation of pancreatic cells, inhibits glucagon secretion, and enhances peripheral tissue uptake of glucose, making it a key factor in maintaining stable blood glucose levels
Safety signals are generated from several sources such as spontaneous reports, clinical studies and the scientific literature
