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For example, the most commonly used treatment is N-acetylcysteine (NAC), which helps replenish glutathione in the liver, allowing it to neutralize toxic metabolites
4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency
Prog Neuropsychopharmacol Biol Psychiatry 64:277284
The effect is dose-dependent
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