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The basic biochemistry is well-established: it is a real endogenous peptide, it genuinely binds copper, it declines with age, and it produces measurable effects on collagen synthesis, wound healing, and gene expression

Aim for an IGF-1 SDS (standard deviation score) between +0.5 and +1.5

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If it is spreading, burning, swelling, or showing up in new places, stop and reassess