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No Rebound Hunger or Metabolic Adaptation Appetite suppressants that work through central mechanisms (GLP-1 agonists, sympathomimetics, serotonergic agents) typically create tolerance over time, requiring dose escalation, and often produce rebound hunger when discontinued
Pairing the eventual reintroduction with hydrating support like hyaluronic acid can help
Step back if GI side effects become intense
Either way, seizures can occur from electrolyte imbalance
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